I've never used Advantage, but all of the 2nd tier car rental companies seem to be the same. In addition to the comments already made, 2 more factors to consider. One is if the car breaks down en-route; chances are the majors (Avis, Hertz, Budget, etc.) are more likely to have a location nearby and able to switch cars. Also the majors tend to have cars in better shape. A more important consideration is that the 2nd tier companies tend to be sticklers for damage if you decline their CDW ... very quick to charge $1000 for a new windshield if a rock happens to nick the windshield during the trip, for example; also for nicks in the paint from road debris (not accidents). While the majors ignore that and treat it as normal wear and tear. On a cross-country highway trip you have a pretty good chance of getting some rock chips on various parts of the car.