Originally Posted by Non-NonRev

Assuming you are at the Royal Meridien (not the Stillhorn), you can walk to and from the main train station - it's about four blocks. The neighborhood in back of the Hbf is not luxruious but safe enough for your short walk.

I STRONGLY recommend buying your DB train tickets and getting your seat reservations online on the DB website. Setting up an account on the english-language part of the DB sie is easy - you can not only get your tickets and reservations taken care of at one time, you can then print the actual boarding pass (you can also save the ticket/boarding pass image as a .pdf file for re-printing use, if needed). (Also, IIRC, you get a discount on the seat reservation fee if you do it online). Don't forget to book your return from Berlin too!