Originally Posted by GUWonder
For better or for worse, I've taken the E train over to the E50s (under the Citibank building at 53rd & Lex) from Penn Station and transferred to the 6 until 86th and then transferred to the express train up to Yankee Stadium. (But this was because walking outside was worse than suffering the subway.) The better thing to do is usually to walk on 34th -- or better yet 32nd -- and get the D train.

Thats an option too, but it could get nasty around 53rd street station.
Also a lot of stairs over there.
In this case D is a simple option.