ALL the reviews I've read on the Wynn's service is negative, unless you're gambling, then they treat you extremely well, even if you're bets are not that high.
To me, Skylofts can't seem to be beaten.. I was planning a 4 night stay in a 2BR through AMEX FHR (upgrade to 3BR if available) at just under $1200 a night (incl taxes) (3BR = $6500) I even booked each night separately in order to maximize my chances for upgrade

The late checkout/early checkin overlapped, and you checkin from your room, so it's not even more work to do.
But I ended up spending a lot more on my upcoming EU trip, and I already have condos booked for 2 weeks in Vega anyway. (Family trip)
To be clear, I see no BOOKABLE rooms (not controlled by casino) that are superior to Skylofts in terms of quality/size/service/rate.
They are all lofts, 1BR = $600, 2BR = $1200, 3BR = $6500 (weekday rates) F/S/N rates are significantly higher.
The FS is significantly more expensive for suites, if I remember correctly, however the two differences would be traditional interiors instead of modern, and being off the strip.
Also, THEhotel seems to have some nice suites, M might have 3 sides of glass walls, and L is similar to 2BR Skyloft in size. I'll see if the floorplans are still up. The rates for them are comparable to Skylofts, but the concierge/butler services are NOT complimentary, as they are at Skylofts.
THEhotel floorplans >
http://www.natpe.org/conference/exhi...ctionSpace.pdf
http://www.tripadvisor.com/Search?lc...=203463&ssrc=r
Hmm, 5 reviews on tripadvisor now for Skylofts. They all look like very good ones
Review of Wynn > gambled and got comps, stayed in (ridiculously overpriced) villa
http://www.ratevegas.com/blog/2005/1..._vegas_24.html