danielonn,

As you may have seen from using the Great Circle Mapper program, when you enter the city combination of SFO and TLV, the flight path from SFO starts heading Northeast through Canada, Greenland, western tip of Scandinavian pennisula, Germany, Turkey before getting to TLV for a total distance of 7422 miles. It may be doable as a non-stop on a B747-400 since LAX-SYD (7488 miles) is done using a B747-400. If it needs to be one-stop then I think it is a shorter trip to go through JFK rather than say going the long way through NRT. SFO-NRT-TLV is doable on B747-400 since each leg is about 5100 and 5700 miles. It would be a good MR to go through NRT to earn miles, though.

HJ