Originally Posted by swise
You really should be fine. I haven't used Windows in about 8 years, and the number of times there's something I can't access due to incompatibility is miniscule. Maybe a couple of times a year there's an .exe file somewhere that I can't immediately access...
In this context, many of the .exe files I've needed to use on a Mac have been self-extracting compressed files where the executable part is the decompression code and the underlying file is Mac-compatible (like PowerPoint). Stuffit Extractor is quite happy to ignore the Windows-only executable self-extraction code and pull out the PowerPoint file; it just has to be told to do it, since the .exe extension keeps the system from figuring that out on its own.
This is not to deny that there are a zillion Windows-specific things out there, I have VirtualPC for those, but this is one not-too-rare case where something that looks Windows-specific on the surface really isn't.