On a long flight, between eating, sleeping and movie watching, I rarely get up more than 4 or 5 times and try to stay up at least 10 or more minutes each time. I have warned the person on the aisle to let me know before they get too comfortable so I can take a stretch and do what needs doing.

My wife is a window person and I am a very sound sleeper. Once asleep, she has quiet a struggle to get by. She has learned to climb over as chances of waking me or slim. When traveling alone in business or with a friend of seating is 2-2-2, I go for the middle two. I have pressed my wife to do that but she likes the window view even though it is often dark or over water with nothing to see. Sometimes it offers extra storage or a place to rest one's head.

I'd find once an hour annoying. When driving we stop every two hours or so and that seems enough.