Nope, standalone units or mobile devices only.

Back in the old days when I used a Mac I knew the folks behind Route 66. Now it is many years later, and they still seem to be the only ones out there for the Mac:

http://www.amazon.com/gp/product/B00...lance&n=229534

But as you will see; the reviews are not very postive. It doesn't seem like there is much of a market for Mac navigation software. But I'm sure one of the Mc'Regulars will pop in with some better advice.

Of course, there is always Google Earth but you'll need to be online to make the best use of that app:

http://earth.google.com/download-earth.html