Well, you have come to the right place, but you will have to be a bit more specific. You can pose specific questions here (i.e., anyone know who has the lowest FF miles required to get to Alaska or Hawaii?), or you can follow the news of the specific airlines for which you have a lot of miles (why bother following news of United if you have no United miles). For example, last year someone posted that Delta had an award "sale" and certificates for domestic US travel, usually 25,000 miles, could be obtained for 20,000 miles for a limited period of time. With 80,000 miles, just slightly more than three tickets normally, I instead picked up four domestic US coach tickets. So, if you want to catch things like that,you have to keep abreast of what's being posted here.
As to one specific site that compares each of the airlines for each specific destination, though, I am not aware that such a site exists. Anyone else?
Djlawman
Hope this helps.