Originally Posted by chgoeditor
A lot of people who are very sensitive to drugs take a Benadryl (the "PM" ingredient in Tylenol PM) when they want to fall asleep. You shouldn't take Tylenol if you've been drinking, and generic Benadryl costs a lot less than generic Tylenol PM (you're paying for half the ingredients), so that's another thing to consider. This is non-prescription.
I too vote for Ambien. I used Ambien CR on my recent trip to BKK. On the ORD-NRT leg I had lunch and a few drinks and then washed up and took the CR. Slept about 8 hours and then got up for the next meal. Felt fine and stayed awake on the next flight to BKK. The flight to BKK arrived at midnight local so at 2am local (2pm back home) I took another Ambien and went to sleep. Woke up the next day 12 hours later and was pretty adjusted to BKK time.
As for the Benadryl v. Tylenol PM... Tylenol also makes something called Simply Sleep which is the drowsy causing agent in Benadryl and Tylenol PM without the Tylenol. I find however, that I am much more groggy on any of these than after an Ambien and 7 hours sleep.