Galileo has already been mentioned a few times in this thread, but it is worth mentioning that another option at this restaurant is the Laboratorio del Galileo. Here, you can be one of 30 people to watch Roberto Donna himself prepare a 10-12 course tasting menu. Needless to say, reservations are hard to come by, but if you have the opportunity, it is obviously quite an experience. Website: http://www.galileodc.com/restaurants/laboratorio/