Tried hotwire for my first time recently.
Some potential advantages, sometimes:
Hotwire gives you a quote, held for an hour. Priceline makes you chose the level/quality of location first. So if you're going for one star location, that's pretty much what you get on priceline.
The hotwire bid gave me several options at 33-36 a night in Dallas/Irving. But for 36 I could get a 3 star; one star for 33. So I went for the the 3 star, knowing that a recent post here stated sometimes the hotel special rates end up being cheaper. I didn't know which location, so I took the jump.
Well, the lowest rate at the Los Colimas Garden by Wyndam was 60ish. So I saved 20 per night plus I get free workout privileges at a health club--which I value and cannot get at a one star.
JL2