I used to live in Columbus and found that for the westerly travel that I tended to do, UA was the best. Plus it had better a/c than most of the other airlines (no MD-80s or DC-9s for me, thanks!)
Based on the current timetable, you can get to three UA hubs (ORD, DEN and IAD) a total of 19 times a day. To ORD, from whence you can connect to basically the entire country, you're looking at many flights on 757s, which are my favorite in economy (rows 8/9).
Plus UA has a strong Asian network, both on its own metal and on Star Alliance partners. Finally, if you have any faith whatsoever that the US merger will go through, you'll have access to probably the strongest network on the Eastern seaboard.
Mike