The Airbus A380 will be cheaper to operate per paying passenger than any sonic aircraft.
In general, the flying public wants cheap air travel more than they are willing to pay a premium for faster air travel.
Just look around -- most of us get excited if we can save $10 or $20 on a ticket. Some of us will take flights with extra connecting cities just to get a few hundred more frequent flyer points. We all want to get their cheaper more than we want to get there faster (unless your flying on the company's dime).
Do you think we're gonna pay $500 for a ticket when we can fly the same trip for $250? (These numbers are purely wild speculation on my part)
Maybe after we get used it, and come to expect the faster speed. But I'll bet Boeing is going to struggle harder than they ever have before to get this one into profitability. That is, if the plane ever even sees the light of day.