Behavioral profiling is used at BOS but it is done by the PD (MA State Troopers, if I remember correctly), not TSA.
I have only heard the LEO side of it, and they believe it is a fantastic system to select travelers for additional screening. They claim an interview can determine if a person, who at a first glance looks "suspicious", really needs additional screening, or not.
They are also very quick to point out, though, that this method requires additional training of the interviewers and that the TSA screeners, with current training, would absolutely not be the persons to conduct these interviews.
If the interviewers are trained properly I see no problem with this. It would actually be an improvement over the present criteria to select a traveller for additional screening. It would be very interesting to hear from an FTer who has experienced this at BOS.