777 all the way. Theres nothing like it. If F its not as cramped in the nose like the 747. The 777 seems fine tuned to me. Even in Y 2-5-2 is pretty good as long as you aren't in the middle section. The 3-3-3 configuration is bareable too! The 380 doesn;t excite me. I certainly want to fly it but its just too many people. I'm sure the 787 will be the TRUE Dreamliner its billed to be.

The airline hold the keyo to your question however. There are MANY differences between layout and design, seats, and even decor.