Luckily, I have not yet encountered a seriously noisy infant in front cabins but IMO, it is fairly annoying to have someone disturb peace for any amount of time on any flight.
Infants are NOT full fare paying passengers, so why should they spoil the trip for everyone else? If I pay for the privilege of a bed seat in 1-st then I seriously object to any noise which interrupts my sleep. After all if I pay a good 25 times more for that (bed-seat)privilege then why should I suffer just to be nice?
Would anyone tolerate if someone brought a ghetto blaster on board and turned it up to the same volume as an infant makes? I seriously doubt it. The person would be asked to turn it down and if he was to refuse then he'd probably be restrained and later arrested for disturbing the peace, noise pollution, etc, etc...
Noisy kids should remain in coach as they have nothing to do in business (unless they are a business accessory) nor in 1st. However, I do not blame the kids but rather their parents who should have more respect for their fellow premium travellers. Bringing a noisy infant into a premium cabin just shows arrogance and disrespect since most passengers there travel on business and need to be well rested for their upcoming trade meetings.
P.S. I did not mean to offend anyone with my opinion. If I did then I apologise in advance but will still stick to my views.