Originally Posted by kaptan
For your the trip back there is a 5:30 AM Cedaz bus from Namesti Republiky that gets to the airport before 6:00 am. Gives you 90 minutes which is more than enough.
There probably won't be much competition at 5:30 AM but I'd still be at the stop early. We had wait an extra 1/2 hour for the next van when there weren't enough seats for our whole party.