Gosh, too many to count. Right now, get a Hilton Hhonors AMEX Platinum and get 10,000 bonus Hilton points with first use, w/ a possible additional 10,000 for staying a few times at Hilton. Or, get a Bank One Priority Club Visa and get 10,000 bonus Priority Club points with first use. Or, get a Gold AMEX Skymiles and get 12,500 or maybe 15,000 Delta Skymiles with first use. Go to the airline or hotel program you are interested in and usually there is a link to sign up with their co-branded CC w/a hefty signing bonus.