Originally Posted by best
Anything new and very cool?
No. If you want new and cool, go to LA or NY.
Actually, if it's still open, 12 North in Clayton was pretty cutting edge for STL.
And the recommendations above are all pretty solid. If you have only one dinner in STL in your lifetime it has to be on The Hill. Also consider Al's Restaurant - a high end steak joint downtown. Far from cutting edge, but excellent food.