In my experience, Virgin has the most uncomfortable (regular) economy seat among the airlines that fly NYC-LON. Very small pitch (this from a short man), and very uncomfortable lumbar and neck support. Even if you can get to sleep with Ambien, you might wake up with the most painful crick in the neck. YMMV. (See if your employer will allow you to fly premium economy; technically, it isn't business class. If s/he does, then go for VS, and try to snag a seat on the upper deck of a 747.)