Interesting topic. I suggest that we leave RJs out of this and stick with the big mainline jets.
Houston Hobby to Intercontinental comes to mind. Makes for a last minute mileage runs for those in Houston short of Continental Elite status. A couple daily 737s go in addition to the Express flights.
The HOU-IAH add on is free with the flight from IAH, so many people on the Hobby side of town start their journey in HOU for a cool extra 500 miles.