For a family of 5, suite hotels tend to work best. Brands like Embassy Suites, Homewood Suites, or Residence Inn usually have a separate living area and sofa bed, so everyone fits without squeezing into one room.
In Europe though, room size and occupancy rules are tighter. In many cities it’s simply easier to book two rooms or use an Airbnb/VRBO.
If you want to stay with hotels and earn points, focusing on one chain like Hilton or Marriott helps since they have more suite-style properties.