I was in Lyon in December 2024 and also stayed at the IC Hotel Dieu. Nice hotel, great breakfast. I only had a few days there so didn't do any day trips but these were a few highlights:

We had an excellent meal here: https://www.lesenfantsterribleslyon.fr/ - it was an easy walk from the hotel on a street with many restaurants but came recommended and the foie gras ravioli was to die for.

I also really enjoyed the Paul Bocuse food hall: https://www.halles-de-lyon-paulbocuse.com/

If you're interested in history, the resistance museum was interesting and very well done, a long-ish walk from the hotel but the Uber we took to return there was inexpensive: https://www.chrd.lyon.fr/musee/resis...history-centre

There's also a small history of Lyon museum in the old town but there wasn't much English there - most exhibit descriptions were only in French. I know enough of the language to understand some of it but it wasn't very extensive and I wouldn't necessarily recommend it if you have limited time there.