it’s ~900 miles and ~14.5 hours drive time *each way* MEM<>BUF
*if* I decided to drive this round-trip, I’d stay *two nights* in the vicinity of Mansfield OH; that splits the trip into two ~600 mile/11 hr days MEM<>MFD, with the middle day being ~500 miles/8 hrs up-and-back MFD<>BUF to exchange cars
the AAward flights like those guv1976 mentioned are rather more pricey (~12k in Y, many with two connections) around Thanksgiving