Two flights, EK215/6 and EK225/6 (DXB-LAX / SFO) fly almost over the North Pole (max lat. 86 N) and a large airportless swath of icy sea and two other flights (QF63/4 and QF27/8) fly over remote airportless ocean from SYD to and from JNB resp. SCL. Yes, I know, it is ETOPS certified and an A380 should even not conform ETOPS rules, but, yet, emergency landings are not always option.
Imagine, when something happens on board (multiple engine flameout or, worse the horror scenario of engine fire or cargo basement fire), what happens when there is no airport accepting an A380 (SYD-SCL is 789) within thousands of miles ? Ditching into the ocean or landing crashing on icebergs in the Arctic, like the NZ case of the DC10 disaster in Mount Erebus in the 1980s ?