I would concur with JonNYC that Swiss A340 has an excellent Business Class Seat and service, and transiting in Zurich would be easy depending on the Swiss connections to your final destination.

However, you would have to change planes from SFO for the direct service LAX-Zurich, or worse change in NYC. Not the best option if you have onward transit in Europe as well.

Steer clear of Iberia and Aer Lingus as advised elsewhere.

The British Airways Fully Flat Beds in Club World are great, and you get a the use of the Molton Brown Spa at Heathrow for a massage.

From a flyertalker perspective, it's fun to check out the upper deck of a 747 (as an AA flyer that wont have happened for you for a while?) and also to take off facing backwards if you have a window seat, as well as the general interest in flying an airline you might not have been on in a while.

You have to get to Vancouver/Toronto/Montreal or Mexico City (ie outside continental US) to redeem AAdvantage Miles on BA, but there are multiple onward connections to most cities in Europe in the Club Europe Cabin (free bar lounge access, champagne and full meal onboard, slightly larger leather seat) and LCCs can get you ex SFO to these destinations for small pennies, or you can try a oneworld award on AA to these non-US BA hubs and onwards to London and Europe from there.

But if you have little interest in checking out alternatives for the sake of it, then I think you would probably have a more direct hassle free journey on AA with their Business Class Seats.

http://www.britishairways.com/travel/cwexp/public/en_gb

As an aside, BA have announced the roll out of Second Generation New Club World Fully Flat Bed, with changes in seat coverings and the dividing fan to darker fabric to reflect less light into the cabin at night, softer cushioning for better sleep, and new pillows and blankets.

"Soft" improvements took effect on February 1, 2005. A glass of champagne will now be served prior to take off. In addition to the usual food and bar service, Raid The Larder sandwiches available from a chiller cabinet throughout the journey, along with other snacks. September 11 cutbacks are being rolled back across the fleet.