I agree with previous comments. 4A/K tend to be noisy (especially 4A). I would take a seat in a middle pair any day over row 4... My personal ranking if travelling solo on the A380:
- 2A/K and 3A/K (best seats in the house and pretty much the same)
- 1E/F and 2E/F (no windows but still great privacy and well isolated)
- 3E/F (good, but starts getting a little bit of noise from the galley)
- 1A/K (hate being completely exposed to whoever comes back from the washrooms)
- 4A/K (noisy)