Hoping to get some feedback from those that are more familiar with the city.

First time visiting for 3 nights. Looking to do mostly touristy stuff (souq, museum, desert activities etc.) Trying to determine whether there's an property with "optimal" location, with easy transit/access.

A few that I was considering: Marriott Marquis, JW Marriott Marquis (talk about confusing), Le Meridien, W

The St. Regis looks pretty neat, but seems like it's a bit out of the city. How much does this location affect ease of access to touristy activities?