I don't need (or care) much for pampering. My honest programs are:
Airline:
WN - Punctual and the feeling that I'm not nickeled and dimed for everything, especially when the unexpected forces me to change plans at the last minute. Easy redemption.
Hotel:
PC - Given their numerous locations, generous points and liberal redemption, I have no complaints. Everywhere I go, there always seem to be one, two or even more to choose from...not much or no choice sometimes in case of other chains.
Hyatt - Easy to understand and follow program. Generous bonus points. FFN's. Only downside: there's not that many of them.