Always intrigued by how folks select seats. I agree with all that has been said. In fact I am in 3A in both directions for my next HND/FRA flights. Another consideration for me is Toilet Traffic. Akin to galley noise I find the foot traffic to/from the bathroom a tiny annoyance and so I try to sit midway between the bathroom locations when they are both fore and aft of the Business cabin. This however applies more to European airlines for me as the folks from those locations seem to sleep less (absolutely zero scientific analysis there ) than the pax from my host country here.