Originally Posted by
etiene
The issue with the wildcards in the US is that they can and will bump you through any number of airports in the middle of the country [not just the hubs], resulting in crossing the country for only 80 TPs rather than 140. I generally think it's better to list the hubs, remembering to avoid ORD, DFW, PHX-CLT and PHX-MIA [though I rarely find any decent availability through MIA].
You can also negate any entry with ~
So ~DFW,ORD will act as X without DFW or ORD