I have sympathy with the OP as well as the crew. The former because it's self-evidently annoying if you are trying to get rest, or relax etc. but the latter because they do need to communicate and get the job done (and I can't begrudge them some "yapping" in between).

My advice to OP would be to maybe give it a few minutes. Quite often the chatter dies down quickly enough. Failing that, as others have pointed out, a polite request to keep their voices down as much as possible will probably do the trick.

There are times when I have been very disturbed by crew noice and activity and other times when it washes over me. There are various variables, but normally a bit of normal "office chatter" does not bother me.

On a recent CE flight the crew and what I think was the despatcher were talking prior to push back on what was a heavily delayed service. I wouldn;t say they were particulalry loud, but you could certainly hear them from row 2, where I was, so row 1 would have been even more impacted. One of the cockpit crew then came on, but the volume was so low that you couldn't hear a thing with the noise from the galley, and Mr 1 D loudly shoooshed them, which personally I would not have done but which certainly had the required effect. I am not sure whether they even knew there was an announcement from the flight deck. If not, then I have some sympathy for both sides, because though the passenger action was maybe a tad rude, it could have been an important announcement and it really was a struggle to hear anything, even if the crew weren't being paticularly loud themselevs. If they knew the pilot was speaking then my view is that they should have stopped talking at that point.