North America? I see many, many flights to San Juan, Martinique, Dominican Republic, Saint Martin, etc.
If you mean solely direct flights to the continental US and Canada - The airport says JetBlue is supposed to have a Monday to JFK and Transat Monday to Montreal. Perhaps they have seasonal service.
https://guadeloupeairport.com/flights/airlines/
EDIT: Transat drops to Thursday only in May, then nothing from 6/13 to 10/31. Jet Blue shows one flight on April 29 then nothing for the next year.