I also get some pretty rough migraines. I've also had a few at work. This is the worst! I can't say whether the cabin pressure has affected them or not because I've been getting them long before I was flying for a living. I personally have found that plain aspirin, taken with coffee, works best for dulling the pain, taken as soon as the vision interference starts. About an hour later, I take two advils. I've learned that avoiding chocolate, for some strange reason, helps also. I remember hearing somewhere that this was a trigger for the headaches, and so far, so good. Also, sufficient sleep is essential. I've noticed that being tired triggers them also. So much for jumpseat medical advice, huh? LOL Take care