I don't generally lock my laptop up in nicer hotels. I am more worried about the data than the actual machine. I always back up my data since I have been rather careless with my laptop in the past. My laptop is company property so from what I know our laptop insurance is pretty good. One time my laptop was completely wiped out (think crash on the floor). using my backup data they were able to give me a new machine with all my data in less than a day. If the computer won't fit in the safe and you have particularly sensitive data on your machine I suggest popping out the hard drive and sticking that in the safe. My hardrive comes up with undoing exactluy one screw. My work provides us with kensington cables and I will sometimes bolt my computer to the desk if I remember.