I seem to get a lot of migraines when and after I fly. I've discussed this with a neurologist, and he agreed that the pressure changes due to flying can be a trigger for migraines.

I often rely on nasal spray administered medications when I fly. I don't want the hassle of carrying needles onboard with me, and many times I can't keep anything down with the nausea. The drawback is that I sometimes lose some of the liquid when I open the container to affix the nozzle to the bottle. The pressure change inside the bottle actually causes the medicine to jump out of the container when the top is removed. I literally feel like the same thing happens behind my eye.

I'm wondering if anyone else has noticed a correlation between migraines and flying.