Much of this kind of thing is a matter of opinion, but these are mine, fwiw.

There's two "Needles" areas of Canyonlands. There's the Needles district with the Needles Visitor Center and there's the Needles Overlook. You shouldn't miss the Needles Overlook (a drive on a paved road from Hwy 191 between the turn-off to the Needles District (Hwy 221) and the turn-off to Island in the Sky north of Moab (Hwy 313). There's no hiking to do there but the view is great in the morning (the viewpoint faces west). I don't recall a lot of great views from the roads in the Needles District, however, but that may simply be my taste.

Although you can see the cliff dwellings in Mesa Verde from the road, it's much more interesting IMO to visit the sites on a tour. Tours have to be booked on recreation.gov and you will need to read the description carefully to make sure your wife can handle any stairs or ladders. Tours start in May, I believe so there may not be any available when you visit. Not all the tours involve ladders but some do.

It's been several years since I've been to Hovenweep but I'm not sure how impressive it would be if you aren't going to take the 2 mile hike around it and saw Mesa Verde the previous day.

I would consider Natural Bridges National Monument, if you've never been and your wife could handle the short hikes to the bridges. The best bridge, IMO, is Owachomo and the hike is about 0.4 miles round trip. There isn't a reason to visit Natural Bridges if 0.4 miles is too long a hike.

It might be worth thinking about whether there are any short hikes your wife could do. I recommend the Mesa Arch loop in Canyonlands (0.6 miles total) for sunset or sunrise.