I would as you may find $100 bills hard to break at some stores who may have signs saying due to counterfeits they aren't accepted.

At others it may depend more upon what you're buying as trying to break a $100 bill for a bag of ketchup chips at a convenience store, for example, may be refused but may not be if you're purchase is higher, like $40 or $50, at a restaurant.

Canada has one of the highest usage rates of plastic payment - CC & debit - in the world so some stores just don't have as large a cash float as they used to meaning breaking bigger bills becomes that much harder.