It would be helpful to specify which hotels you've booked.
I've stayed for long stays at the Buena Park Residence Inn, as well as the Townplace Suites and Fairfield Suites in Manhattan Beach (the two are next door to one another).
Without a doubt, in terms of stay comfort and value, the Buena Park location is superior. The Residence Inn has true bedrooms and kitchens, whereas most of the rooms in the Manhattan Beach hotels are studios. Some rooms in the Townplace Suites face the light rail, and trains rattle by every few minutes.
Again, this is based on the hotels only, not location.