We go for the 4 across - watch out for the offset (why???) numbering using the online seat map as a guide - drives me nuts. But have also done the 2-2/2-2. Just a preference that one adult can see across the row if the other is sleeping whereas with 2-2/2-2 there is no chance. It is almost like you are not flying together.
Yes you can step in front of the centre console, it is tight but doable, but plenty of secure hand holds to up and over the bed if it is reclined. More difficult if both beds are reclined and you are on the window. I tend to do the go through the galley, my wife does the parkour over the top!