Most network airlines run hub-and-spoke. However those hubs are getting more spokes, which reduces the number of city-pairs where going through multiple hubs is required. It wasn't that long ago that someone flying, say, IND-PRG would have to fly (ATL/CVG/JFK)-CDG or (DTW/MSP)-AMS or (ORD/IAD)-FRA or (ORD/DFW)-LHR, now it's IND-CDG-PRG or IND-JFK-PRG (or equivalent on other alliances/JVs).