I don't think I would do macchu piccu in a weekend. But I have been to Hong Kong and Paris on weekend trips. You basically just get a taste of the place and now I try to not overdo, just focus on a single area (such as kowloon/victoria peak in Hong Kong) otherwise it's overwhelming.
Analise - I don't know why I didn't like Amsterdam too well. Maybe because it was very cold when I was there. We did go around Delft to see the seashore, which looked gorgeous, but it was so cold when I was there I couldn't really enjoy it. I would love to go back in the summer. One of the most amazing waterparks I've ever seen was in some neighborhood of Amsterdam, also an incredibly beautiful sculpture garden that I have never forgotten. I think I will have to give it another try! I also loved the afternoon teas, which seemed expensive at the time, but maybe will seem reasonable after living in NY.