Oh, please.

As I wrote above, things have definitely deteriorated in terms of homeless people, drug use, etc. However, as two seconds of Googling would tell you, that hasn't translated into high rates of violent crime, and to my mind, violent crime is what I think of when I think of safety. It may "look" messed up, but in reality, the homeless people and so on are (mostly) not about to attack you physically.

Also, it's kind of funny to read people in this thread talking about how things are around this hotel when by their own admission they have stopped going to SF. I, on the other hand, have not stopped going to SF, Berkeley, Mountain View, San Jose, etc. I stayed in this hotel with my wife and young son just two months ago. The most disturbing thing that happened was when some anti-mask hippie (yep, they exist) in the lobby of the hotel (not a homeless person, an [expletive] who was a hotel guest) started berating me for wearing a mask indoors.

This is a pretty decent Regency, with an actually open Club (though it doesn't really serve anything but snacks except at breakfast), decent rooms, especially if you choose one of the "deluxe king" options with a nice view facing south. Staff are friendly and helpful.

Then again, we stay in the Bay Area not as tourists but as former Bay Area residents and we spend our time visiting friends and I also come on business trips all the time.

Don't be frightened away by folks who can't stand seeing homeless people once in a while. SF is in the lower tier of violent crime of major cities in the US.

London Breed has instituted a crackdown on open air drug use - it's controversial but it's not as though the city is unaware of these problems. And as I noted before, crime is down this year already. Times change, then they change again.