Literally all very frequent BA routes have weekly commuters - be they shorthaul (NCE, GVA, FCO, MAD, BRU, etc) or long haul (JFK, TLV, previously HKG, etc).

However exhausting you may feel it sounds, it still pales in comparison to weekly commuters on connecting flights - for instance I knew someone who used to fly every weekend between the US and TLV via LHR on BA, and another who used to fly every weekend between BOS and FLR (not on BA). The latter sounds shorter but was probably worse given the paucity of flights to FLR and how often that airport closes down especially in the winter.