I-81 is scenic, in theory. But it tends to have heavy truck traffic. If you have time, there are scenic (but slower) drives through the Shenandoah Valley. The last time I was out that way, I detoured through Shenandoah National Park. Route 11 is another option.

I've also been known to get off 95 north of Fredericksburg (which is worth a stop) and go up 123.