At least at IAH and ORD, CBP had one-stop immigration/customs which allowed some international arrival passengers who were carry-on-only to self-segregate from those international arrival passengers with checked luggage. But even at such airports which had managed to have a separate process for passengers with checked luggage than for some passengers who had only carry-on luggage, for us to get to one-stop security at US airports -- as happens at some Schengen airports of entry (to the Schengen zone) -- an airport and CBP would have to:

1) control/monitor the international gates so as to more readily block prevent mingling between"white-listed" arrival passengers and other passengers; and/or
2) set up one or more airside transit passenger screening checkpoints/routes available to deplaning passengers.

With checked luggage, the issue becomes more complex because CBP is not well-inclined to do progressive clearance of international arrival checked luggage at downstream/onward US airports, but there are back-end processes that could be used to deal with that issue with some investment and perhaps some more international cooperation on the checked luggage process outside of the country.

I could foresee MSP having one-stop security screening in place for flight arrivals from the Schengen area at times when a MSP terminal happens to have no international flights coming in from Mexico or other non-EU/non-Schengen airports without CBP Preclearance. There are even ways to deal with the checked baggage issue that is not dependent upon implementation of progressive screening and/or some kind of checked-in luggage-specific preclearance. I could also foresee ATL or DTW being able to do this.