Originally Posted by
NYCRachel
Would 100% stay downtown. Subway from downtown (depending on where you stay and your destination) can be anywhere from 10-20 minutes to those locations. By no means a dealbreaker, but consider staying on the NRQW line as that line will likely result in the fewest (if any) transfers, given it criss-crosses Manhattan.
Broadway Line (NQRW) is the key to tourism until you want north of 59th St., heck you can even walk from the Q to Museum Mile 82nd - 110th.
https://www.nyc-arts.org/collections.../museum-mile-2