During the pandemic, I was able to take many two-night trips with a single backpack, but boy, was that sucker heavy. Now that my weekly trips have expanded to 3-4 nights, I have adjusted to a single carry-on roller bag (measured to the maximum carry-on size) and a smaller laptop bag. I've even been able to do 10-night trips with that setup, at least in the summer (winter coats and long pants are such a space hog).