The first M60 bus leaves 106th and Broadway in
Manhattan at 4 A. M. The buses run every 20 minutes from 4 A. M. everyday. It takes between 35 and 45 minutes to reach LGA, depending on to which terminal you are going.
For information on the M60 bus, specifically, go to
http://www.mta.nyc.ny.us/nyct/bus/sc...nh/m060cur.pdf.
For information on other bus and subway routes throughout New York City go to
http://www.mta.nyc.ny.us/
Have a good trip.